Effect of the esterase inhibitor BNPP (25 mg/kg p.o.) in neutral water and GFJ (10 ml/kg) on the PK parameters of lovastatin acid and enalaprilat following oral administration of lovastatin and enalapril, respectively (10 mg/kg) to rats
Data are mean values ± S.D. (n = 3).
Coadministration | Enalaprilat | Lovastatin Acid | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AUC0-24 h | Tmax | Cmax | AUC0-24 h | Tmax | Cmax | |||||
| nM · h | h | nM | nM · h | h | nM | |||||
| Water | 5743 ± 303 | 1.0 ± 0.0 | 2543 ± 255 | 45.3 ± 6.20 | 1.3 ± 0.6 | 10.2 ± 1.25 | ||||
| BNPP | 9006 ± 1292 | 1.0 ± 0.0 | 3963 ± 1410 | 109 ± 12.5 | 1.0 ± 0.0 | 34.2 ± 11.6 | ||||
| Water (pH 3.5) | N.D. | N.D. | N.D. | 57.5 ± 24.1 | 3.3 ± 1.2 | 14.8 ± 3.3 | ||||
| GFJ, 1:3 diluted (pH 3.5) | 9465 ± 1886 | 1.0 ± 0.0 | 4063 ± 635 | 218 ± 140 | 2.3 ± 1.5 | 61.0 ± 41.4 | ||||
| GFJ, 1:2 diluted (pH 3.5) | 9743 ± 1560 | 1.0 ± 0.0 | 3790 ± 719 | 148 ± 56.3 | 4.0 ± 0.0 | 34.8 ± 12.6 | ||||
| GFJ, concentrate (pH 3.5) | 6643 ± 1949 | 4.0 ± 0.0 | 1443 ± 468 | 155 ± 38.0 | 4.0 ± 2.0 | 38.0 ± 16.1 | ||||
N.D., not determined.