Mean pharmacokinetic parameters of prasugrel metabolites in humans after a single 15-mg (100 μCi) p.o. dose of [14C]prasugrel
Parameter | 14C | M2 R-95913 | M3 R-138727 | M5 R-106583 | M7 R-119251 |
|---|---|---|---|---|---|
| AUC0-12 (ng · h/ml) | 2412 | 117 | 122 | 604 | 103 |
| AUC0-last (ng · h/ml) | 6813 | 118 | 122 | 827 | 104 |
| Cmax (ng/ml) | 546 | 67 | 80 | 120 | 58 |
| T1/2a (h) | 188 | 3.9 | 3.7 | 8.7 | 2.9 |
| Tmax (h) | 0.5 | 0.5 | 0.5 | 1.0 | 0.5 |
↵ a Median half-life values reported.