TABLE 2

Metabolites of prasugrel identified by LC/MS in human plasma, urine, and feces after a single 15-mg (100 μCi) p.o. dose of [14C]prasugrel

Metabolite
[M + H]+a
Characteristic Product Ions (m/z)b
M1-A—D 336 149, 177, 206, 318c
M2-A, B (R-95913) 332 135, 149, 177, 206, 285, 303, 314d
M3-A, B (R-138727) 350 138, 172, 177, 206, 316, 332d
Derivative of M3 498 149, 177, 206, 318, 348
M5-A, B (R-106583) 364 138, 177, 206, 298, 316, 318c
M6 (R-100932) 364 149, 177, 206, 316, 346c
M7-A (R-119251) 469 177, 206, 248, 304, 317, 348, 382, 388d
M7-B (R-119251) 177, 206, 248, 304, 317, 348, 382d
M8 (R-118443) 469 149, 154, 177, 206, 264, 348, 382d
M9 318 149, 177, 206, 272, 273, 300d
M10-A 380 177, 206, 273, 317, 318, 336, 362c
M10-B 177, 206, 273, 317, 318, 336, 362c
M11-A—D 380 206, 270, 317, 318, 336c
M12-A, B 334 149, 177, 206, 316c
M13 508 177, 206, 332c
M14-A, B 540 149, 177, 206, 298, 318, 364c
M15 540 149, 177, 206, 318, 364c
M16-A, B 556 149, 177, 206, 273, 318, 362, 380, 493, 538c
M17-A 556 177, 206, 317, 318, 424, 493c
M17-B 149, 206, 316, 317, 380, 424, 493c
M17-C 206, 317, 318, 424, 493c
M17-D 149, 206, 317, 318, 380, 424, 493c
M18-A, B 348 135, 149, 177, 206, 302, 330c
M19-A—D 524 149, 177, 206, 330, 348c
M20-A—D
318
109, 135, 149, 177, 206, 300c

  • ↵ a Accurate mass data only obtained from urine.

  • ↵ b Bolded ion represents largest product ion in spectrum (without regard to parent).

  • ↵ c Characteristic product ions obtained from urine.

  • ↵ d Characteristic product ions obtained from plasma.