Concentration and pharmacokinetic parameters of tibolone metabolites in plasma at necropsy
Values have been rounded to the nearest integer; tibolone was not detectable.
3αOH-tib | 3βOH-tib | Δ4-tib | 3αS,17βOH-tib | 3βS,17βOH-tib | 3αS,17βS-tib | 3βS,17βS-tib | |
|---|---|---|---|---|---|---|---|
| A. Concentration (ng/ml) | |||||||
| Sampling Time | |||||||
| 1 h | 30 | 2 | 2 | 32 | 11 | 342 | 105 |
| 1.25 h | 6 | 1 | 1 | 23 | 19 | 885 | 464 |
| 2.25 h | 10 | 0 | 1 | 18 | 5 | 499 | 223 |
| 4 h | 1 | 0 | 0 | 5 | 4 | 438 | 318 |
| 6 h | 1 | 0 | 0 | 7 | 4 | 95 | 79 |
| 24 h | 1 | 0 | 0 | 2 | 0 | 36 | 4 |
| B. Pharmacokinetic Parameters | |||||||
| Parameter | |||||||
| AUC0-24 (ng/ml · h) | 58 | 3 | 7 | 151 | 74 | 3541 | 2079 |
| Cmax (ng/ml) | 30 | 2 | 2 | 32 | 19 | 885 | 464 |
| Tmax (h) | 1 | 1 | 1 | 1 | 1.25 | 1.25 | 1.25 |