AUC of tibolone metabolites and ratios and percentages of the metabolites in plasma and safety tissues
Ratios and percentages calculated using AUC and rounded to one decimal place and integers, respectively.
Plasma/Tissue | AUC | Percentage of 3OH Metabolites | Tissue Ratio Δ4-tib/(3α OH + 3β OH) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3α OH-tib | 3β OH-tib | Δ4 -tib | 3α S,17β OH | 3β S,17β OH | 3α S,17β S | 3β S,17β S | Total S | Mono-S | |||||||||
| ng/g · h | |||||||||||||||||
| Plasma | 58 | 3 | 7 | 151 | 74 | 3541 | 2079 | 99 | 4 | 0.1 | |||||||
| Endometrium | 22 | 3 | 66 | 18 | 9 | 822 | 441 | 98 | 2 | 2.7 | |||||||
| Myometrium | 38 | 5 | 57 | 18 | 6 | 566 | 698 | 97 | 2 | 1.4 | |||||||
| Mammary glands | 31 | 2 | 37 | 13 | 7 | 896 | 515 | 98 | 1 | 1.1 | |||||||
| Mammary fat | 88 | 4 | 101 | 10 | 4 | 520 | 326 | 90 | 2 | 1.1 | |||||||