TABLE 3

Concentrations of tibolone and nonsulfated and sulfated metabolites and percentages in monkey feces samples

See Table 1 footnotes. The mean (± S.D.) weight of feces is 57 ± 4 g and 61 ± 4 g after sd and md, respectively.

Sampling Time	Mean Level (± S.D.) of Metabolite Measured (ng/g)
Sampling Time		Tibolone	3αOH-tib	3βOH-tib	Δ⁴-tib	3αS,17βOH-tib	3αS,17βS-tib	3βS,17βOH-tib	3βS,17βS-tib	Sulfated	Mono-S
Single dose
Predose	0	0.0 ± 0.1	0.4 ± 0.5	0.0	1 ± 1	0.0	0.1 ± 0.3	0.0	57.3	100.0
0-24 h	16 ± 23	250 ± 181	401 ± 462	70 ± 64	91 ± 81	71 ± 93	505 ± 505	67 ± 110	48.7	81.2
24-48 h	12 ± 8	280 ± 108	437 ± 247	57 ± 38	107 ± 54	59 ± 73	372 ± 259	43 ± 44	41.7	82.4
48-72 h	6 ± 5	150 ± 131	97 ± 94	25 ± 22	56 ± 20	44 ± 67	103 ± 80	22 ± 33	43.4	70.7
72-96 h	0	48 ± 47	14 ± 10	2 ± 1	15 ± 12	16 ± 24	32 ± 42	7 ± 12	53.5	68.8
96-120 h	0	22 ± 22	5 ± 5	1 ± 1	10 ± 8	7 ± 8	3 ± 3	2 ± 3	45.6	61.5
120-144 h	0	4 ± 4	1 ± 1	1 ± 1	2 ± 4	2 ± 2	1 ± 2	1 ± 1	45.6	52.0
144-168 h	0	8 ± 14	6 ± 14	4 ± 8	7 ± 11	2 ± 3	3 ± 8	2 ± 5	40.9	71.0
0-168 h	33 ± 14	762 ± 103	960 ± 226	126 ± 30	293 ± 48	201 ± 106	1020 ± 313	144 ± 80	44 ± 7	82 ± 4
Multiple dose
-24-0 h	33 ± 28	664 ± 238	707 ± 381	94 ± 121	236 ± 318	427 ± 495	248 ± 338	284 ± 345	43.5	40.5
0-24 h	38 ± 21	719 ± 395	654 ± 324	118 ± 49	415 ± 302	823 ± 875	377 ± 306	476 ± 493	56.7	37.9
144-168 h	63 ± 39	880 ± 485	716 ± 400	167 ± 126	273 ± 146	695 ± 491	252 ± 235	370 ± 263	45.5	33.0
Mean ± S.D.	44 ± 30	752 ± 371	690 ± 342	126 ± 103	308 ± 263	648 ± 630	292 ± 285	377 ± 365	42 ± 20	37 ± 21