Male | Female | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M76 | LM76 | C93 | L93 | NP | M76 | LM76 | C93 | L93 | NP | ||||||||||
nmol/min/mg protein | |||||||||||||||||||
Cytochrome P450 reductase | |||||||||||||||||||
Day 28 | 148.9 | 222.4 | 192.2 | 142.5 | 246.0 | 197.1 | 257.1 | 244.4 | 189.3 | 333.9 | |||||||||
(66.6)# | (28.6)* | (45.5) | (39.2) | (76.3)† | (41.7)# | (38.6) | (50.3)# | (48.2) | (74.3) | ||||||||||
Day 65 | 303.8 | 369.2 | 308.2 | 368.9 | 386.4 | 333.4 | 434.9 | 348.2 | 364.1 | 383.7 | |||||||||
CYP2E1 | (83.2) | (108.1) | (84.1) | (85.9) | (127.5) | (79.3) | (67.8) | (58.5) | (57.4) | (43.5) | |||||||||
Day 28 | 0.57 | 1.35 | 0.93 | 0.77 | 1.13 | 1.05 | 1.63 | 1.51 | 1.37 | 1.71 | |||||||||
(0.18)#,† | (0.38)* | (0.24)† | (0.15)† | (0.37)† | (0.30)# | (0.27)* | (0.42) | (0.24) | (0.19) | ||||||||||
Day 65 | 0.74 | 0.99 | 0.76 | 0.84 | 0.79 | 1.16 | 1.32 | 1.10 | 1.35 | 1.11 | |||||||||
(0.17)† | (0.26)† | (0.22)† | (0.13)† | (0.21)† | (0.17) | (0.23) | (0.20) | (0.32) | (0.28) | ||||||||||
CYP2D1 | |||||||||||||||||||
Day 28 | 0.55 | 0.80 | 0.94 | 0.68 | 0.98 | 0.87 | 0.89 | 0.89 | 0.75 | 0.91 | |||||||||
(0.15) | (0.18) | (0.35) | (0.10) | (0.33) | (0.24) | (0.16) | (0.23) | (0.19) | (0.19) | ||||||||||
Day 65 | 1.11 | 1.20 | 1.20 | 1.25 | 1.25 | 0.87 | 0.85 | 0.94 | 0.85 | 0.82 | |||||||||
| (0.28) | (0.31) | (0.34) | (0.30) | (0.32)† | (0.34) | (0.26) | (0.29) | (0.29) | (0.09) |