TABLE 2

Area under the curve values (mmol/min/l) for ABP, AF, PAS, and SMZ elimination

Area under the curve values (mmol/min/l, mean ± S.D., n = 3) were determined by the trapezoidal rule using GraphPad Prism software. PAS, SMZ, ABP, or AF (50 mg/kg) was dosed by i.p. injection to age- and sex-matched wild-type and knockout mice. Four sequential blood samples were drawn and analyzed for parent and metabolite compounds as described under Materials and Methods.