TABLE 1

Area under the plasma concentration-time curve of wild-type mice after oral topotecan administration with or without different oral doses of Pluronic P85 or Tween 20

Mice receiving topotecan (1 mg/kg) orally were given an oral dose of Pluronic P85 (100, 250, or 500 mg/kg) or Tween 20 (50, 100, or 250 mg/kg). The plasma concentration of topotecan was then determined. Results are expressed as means ± S.D. (n = 3-6).

AUC oral
h μg/l
-Excipients 41.2 ± 13.6
+Pluronic P85
100 mg/kg 54.7 ± 5.4
250 mg/kg 82.0 ± 26.3*
500 mg/kg 58.0 ± 15.0
+Tween 20
50 mg/kg 62.9 ± 17.5
100 mg/kg 82.1 ± 18.1*
250 mg/kg
53.5 ± 20.5

  • ↵* p < 0.05, significant difference between doses with and without excipients by ANOVA followed by Dunnett's test. Data were taken from Fig. 1.