Area under the plasma concentration-time curve of wild-type and Bcrp (-/-) mice after oral and intravenous topotecan administration with or without an oral dose of Pluronic P85 or Tween 20
Mice receiving topotecan (1 mg/kg) orally or intravenously were given an oral dose of Pluronic P85 (250 mg/kg) or Tween 20 (100 mg/kg). The plasma concentration of topotecan was then determined. Results are expressed as means ± S.D. (n = 3-6).
AUC oral | AUC i.v. | ||
|---|---|---|---|
| h μg/l | |||
| Wild-type mice | |||
| -Excipients | 56.5 ± 12.0 | 458 ± 97 | |
| +Pluronic P85 | 112 ± 27* | 517 ± 95 | |
| +Tween 20 | 102 ± 25* | 606 ± 86 | |
| Bcrp (-/-) mice | |||
| -Excipients | 206 ± 29# | 785 ± 76## | |
| +Pluronic P85 | 244 ± 65# | 805 ± 79# | |
| +Tween 20 | 237 ± 28## | 888 ± 136# | |
↵* p < 0.05, significant difference between doses with and without excipients in the same animals by ANOVA followed by Dunnett's test.
↵# p < 0.05; ##p < 0.01, significant difference between wild-type and Bcrp (-/-) mice given the same dose of excipients by ANOVA followed by Student's t test. Data were taken from Figs. 2 and 3.