Expression levels of CYP3A4 and CYP3A5 in human liver microsomes
Pool | Donor Identification | CYP3A4 | CYP3A5 | CYP3A5/(CYP3A4 + CYP3A5) | |
|---|---|---|---|---|---|
| pmol/mg protein | % | ||||
| CYP3A5-rich | HH9 | 53 | 12 | 18 | |
| HH48 | 30 | 9.8 | 25 | ||
| HH89 | 38 | 11 | 22 | ||
| CYP3A5-deficient | HG42 | 310 | 1.1 | 0.4 | |
| HG89 | 180 | 1.0 | 0.5 | ||
|
| HK23 | 85 | 0.7 | 0.8 | |