Genotype | Parameter | Dose (nmol/g) | ||||||
---|---|---|---|---|---|---|---|---|
1 | 12.5 | 50 | 100 | |||||
PEPT2+/+ | CL (ml/min) | 0.302 ± 0.026 | 0.377 ± 0.099 | 0.393 ± 0.023 | 0.461 ± 0.057 | |||
t1/2 (min) | 30.4 ± 3.2 | 26.0 ± 9.1 | 25.9 ± 8.7 | 26.6 ± 5.7 | ||||
Vdss (ml) | 11.9 ± 1.9 | 13.7 ± 2.6 | 12.5 ± 2.6 | 10.8 ± 5.2 | ||||
PEPT2-/- | CL (ml/min) | 0.921 ± 0.098 | 0.643 ± 0.148 | 0.509 ± 0.070a | 0.480 ± 0.096a | |||
t1/2 (min) | 19.5 ± 1.5 | 24.8 ± 3.4 | 26.6 ± 6.9 | 29.2 ± 4.2 | ||||
| Vdss (ml) | 15.7 ± 1.7 | 12.7 ± 3.3 | 14.0 ± 3.6 | 13.2 ± 4.5 |
↵ a p < 0.05 compared with the control group at 1 nmol/g cefadroxil.