TABLE 3

Renal pharmacokinetics of cefadroxil after a 1 nmol/g intravenous bolus dose of drug

Values represent the mean ± S.E. (n = 5–7). Statistics were conducted by ANOVA followed by Tukey's test. For a given parameter, means with the same superscript letter are not significantly different (α = 0.05).

Parameter	PEPT2^+/+	PEPT2^-/-	PEPT2^+/+ + Probenecid	PEPT2^-/- + Probenecid
CL_R (ml/min)	0.182 ± 0.002^A	0.554 ± 0.016^B	0.063 ± 0.004^C	0.215 ± 0.008^D
GFR (ml/min)	0.235 ± 0.004^A	0.258 ± 0.007^A,B	0.249 ± 0.024^A,C	0.278 ± 0.012^B,C
f _u	0.82 ± 0.01^A	0.80 ± 0.01^A	0.80 ± 0.02^A	0.79 ± 0.01^A
fe¹²⁰	0.55 ± 0.02^A	0.60 ± 0.02^B	0.41 ± 0.01^C	0.43 ± 0.01^C
ER	0.95 ± 0.02^A	2.68 ± 0.10^B	0.30 ± 0.03^C	0.97 ± 0.03^A
F _r	0.70^A	0.03^B	0.70 ± 0.03^A	0.03 ± 0.03^B
F _r1	0.03^A	0.03^A	0.03^A	0.03 ± 0.03^A
F _r2	0.69^A	0.00^B	0.69 ± 0.03^A	0^B
%PEPT1	4.6^A	100^B	4.6 ± 0.2^A	100^B
%PEPT2	95.4^A	0^B	95.4 ± 0.2^A	0^B

fe¹²⁰, the fraction of administered cefadroxil excreted unchanged in urine over 120 min.