Interday variation of % remaining of ethynylestradiol (50 μM) as a MBI-positive reference and ketoconazole (100 nM) as a MBI-negative reference in the automated CYP3A MBI screening using each substrate
The interday data were obtained from the average of the % remaining data from several different studies in duplicate on three different days.
Midazolam | Nifedipine | Testosterone | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethynylestradiol | Ketoconazole | Ethynylestradiol | Ketoconazole | Ethynylestradiol | Ketoconazole | ||||||
| % remaining | |||||||||||
| Days | 3 | 3 | 3 | 3 | 3 | 3 | |||||
| Mean | 33.7 | 108.0 | 35.7 | 112.3 | 46.9 | 101.8 | |||||
| S.D. | 4.0 | 6.7 | 2.7 | 6.0 | 5.9 | 5.8 | |||||
| CV | 12.0 | 6.2 | 7.4 | 5.3 | 12.5 | 5.7 | |||||