P450 cysteine heme-iron ligand signature (PROSITE: PS00086) of the P450 superfamily and family-specific patterns of P450 families
PS00086 | [FW] | [SGNH] | X | [GD] | {F} | [RKHPT] | {P} | C | [LIVMFAP] | [GAD] |
|---|---|---|---|---|---|---|---|---|---|---|
| Position (CYP2D6) | 436 | 437 | 438 | 439 | 440 | 441 | 442 | 443 | 444 | 445 |
| CYP2D | F | S | A | G | [RHP] | R | [ASVI] | C | L | G |
| Conservation score (CYP2D) | 6.0 | 4.0 | 4.0 | 6.0 | 3.4 | 5.0 | 1.6 | 9.0 | 4.0 | 6.0 |
| CYP1A | F | G | [ML] | G | [KR] | R | [KRQ] | C | [IV] | G |
| CYP2C | F | S | [ATISL] | G | [KR] | R | [IAMVSK] | C | [VAMLP] | G |
| CYP3A | F | G | [NTASLID] | G | P | R | N | C | [ILV] | [GD] |
| CYP7A | F | G | S | G | [AV] | T | [IK] | C | P | G |
| CYP11A + B | F | G | F | G | [VMAS] | R | Q | C | [LVI] | G |
|
CYP19A
|
F
|
G
| [FSC] |
G
| P |
R
| [SAG] |
C
| [VAI] |
G
|
x, any amino acid; square brackets, those allowed at this position; braces, those forbidden at this position.