TABLE 1
Apparent in vitro permeability in the apical to basolateral direction (A→ B Papp) across parental MDCK cell monolayers and ER of bidirectional transport of CP-615,003, CP-900,725, quinidine, prazosin, and triprolidine across MDCK and MDR1-MDCK cells
Compound (2 μM) | MDCK A→B Papp |  |  | ||
|---|---|---|---|---|---|
| MDCK | MDR1-MDCK | ||||
| cm/s | |||||
| CP-615,003 | 2.8 × 10-6 | 4.38 | 26.1 | 6.0 | |
| CP-900,725 | 9.1 × 10-6 | 0.696 | 1.4 | 2.0 | |
| Quinidine | 8.5 × 10-6 | 1.95 | 12.2 | 6.2 | |
| Prazosin | 11.5 × 10-6 | 0.948 | 2.4 | 2.5 | |
| Triprolidine | 20.3 × 10-6 | 0.695 | 0.8 | 1.2 | |