TABLE 7

Cross-species summary of observed versus expected CNS penetration of CP-615,003 and CP-900,725

Compound	Species	CNS Site	Observed K_p	Expected K_p^a	Expected/Observed Ratio
CP-615,003	Rat	Whole Brain	0.162	2.04	12.6
		CSF	0.0102	0.0613	6.0
		ECF	0.00143	0.0613	42.9
	Dog	CSF	0.034	0.267	7.9
	Human	CSF	0.024	0.233	9.7
CP-900,725	Rat	Whole Brain	0.0824	0.903	11.0
		CSF	0.0206	0.0569	2.8
		ECF	0.0145	0.0569	3.9
	Human	CSF	0.0166	0.148	8.9

↵ a Expected K_p values for CSF and ECF are the respective f_{u, plasma} values; expected K_p values for whole brain tissue are the respective f_{u, plasma}/f_{u, brain} ratios.