Compound | Species | CNS Site | Observed Kp | Expected Kpa | Expected/Observed Ratio |
---|---|---|---|---|---|
CP-615,003 | Rat | Whole Brain | 0.162 | 2.04 | 12.6 |
CSF | 0.0102 | 0.0613 | 6.0 | ||
ECF | 0.00143 | 0.0613 | 42.9 | ||
Dog | CSF | 0.034 | 0.267 | 7.9 | |
Human | CSF | 0.024 | 0.233 | 9.7 | |
CP-900,725 | Rat | Whole Brain | 0.0824 | 0.903 | 11.0 |
CSF | 0.0206 | 0.0569 | 2.8 | ||
ECF | 0.0145 | 0.0569 | 3.9 | ||
| Human | CSF | 0.0166 | 0.148 | 8.9 |
↵ a Expected Kp values for CSF and ECF are the respective fu, plasma values; expected Kp values for whole brain tissue are the respective fu, plasma/fu, brain ratios.