Analyte | Species | t1/2 | Cmax | AUC(0-t) | AUC(0-∞) | |
---|---|---|---|---|---|---|
h | ng/ml | ng · h/ml | ||||
Parent | Male rat | 1.36 | 416 | 386 | 388 | |
Female rat | 1.70 | 683 | 624 | 626 | ||
Mean | 1.53 | 550 | 505 | 507 | ||
Male dog | 5.61 | 418 | 1570 | 1620 | ||
Female dog | 4.48 | 585 | 2500 | 2550 | ||
Mean | 5.0 | 502 | 2040 | 2090 | ||
Radioactivitya | Male rat | 8.08 | 1470 | 3440 | ||
Female rat | 9.07 | 1750 | 3730 | |||
Mean | 8.6 | 1610 | 3590 | |||
Male dog | 43.1 | 1570 | 26000 | |||
Female dog | 38.2 | 1750 | 32200 | |||
| Mean | 40.7 | 1660 | 29100 |
|
↵ a Cmax and AUC values for total radioactivity are expressed as ng Eq/ml and ng Eq · h/ml, respectively.