Recovery of VPA and its metabolites in urine after administration of a 100 mg/kg i.v. dose (n = 5)
Animal I.D. | Percentage of VPA Dose Recovered | Total Recovered | ||||
|---|---|---|---|---|---|---|
| VPA | VPAG | Othera | ||||
| A | 6.7 | 80.5 | 8.3 | 95.5 | ||
| B | 8.0 | 76.2 | 8.8 | 93.0 | ||
| C | 5.1 | 85.7 | 8.8 | 99.6 | ||
| D | 9.1 | 80.3 | 12.7 | 102.0 | ||
| E | 6.0 | 70.7 | 8.1 | 84.8 | ||
| Mean ± S.D. | 7.0 ± 1.6 | 78.7 ± 5.6 | 9.3 ± 1.9 | 95.0 ± 6.7 | ||
↵ a Includes the following VPA metabolites; 2-n-propyl-2-pentenoic acid, 2-n-propyl-3-pentenoic acid, 2-n-propyl-4-pentenoic acid, 2-n-propyl-3-oxopentanoic acid, 2-n-propyl-4-oxopentanoic acid, 3-hydroxy-VPA, 4-hydroxy-VPA, 5-hydroxy-VPA, 2-propylsuccinic acid, and 2-propylglutaric acid.