Animal I.D. | Hill Parameter Estimates for VPA Overall Elimination from Plasmaa | Hill Parameter Estimates for VPAG Formation in Urineb | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Vmaxapp | S50app | n | Vmaxapp | S50app | n | |||||
μ mol/min/kg | μM | μmol/min/kg | μM | |||||||
A | 2.43 | 40.3 | 2.83 | 1.90 | 71.9 | 1.54 | ||||
B | 2.31 | 109 | 2.13 | 1.44 | 104 | 1.37 | ||||
C | 2.43 | 106 | 1.90 | 1.82 | 86.0 | 1.35 | ||||
D | 2.91 | 180 | 1.56 | 1.94 | 111 | 1.18 | ||||
E | 3.06 | 154 | 1.90 | 3.40 | 215 | 1.25 | ||||
Mean ± S.D. | 2.63 ± 0.33 | 118 ± 53 | 2.06 ± 0.47 | 2.10 ± 0.75 | 117 ± 56 | 1.34 ± 0.14 |
↵ a Estimated from fitting unbound VPA plasma concentration-time profiles to a two-compartment model with elimination characterized by the Hill equation (Fig. 1).
↵ b Estimated from fitting plots of valproic acidglucuronide urinary excretion rate versus unbound VPA plasma concentrations to the Hill equation. (Fig. 3).