6-OH-Buspirone | Buspirone | |||||
---|---|---|---|---|---|---|
5 mg/kg | 10 mg/kg | 5 mg/kg | 10 mg/kg | |||
Route | i.a. | p.o. | i.a. | p.o. | ||
CL (ml/min/kg) | 47.3 ± 3.5 | 68.7 ± 8.7 | ||||
Vss (l/kg) | 2.6 ± 0.3 | 2.5 ± 0.3 | ||||
t1/2 (h) | 1.2 ± 0.2 | 1.2 ± 0.3 | 0.9 ± 0.4 | 1.0 ± 0.0 | ||
Cmax (μM) | 0.59 ± 0.16 | 0.04 ± 0.02 | ||||
tmax (h)a | 0.25 (0.25-4.0) | 4.0 (0.25-4.0) | ||||
F (%) |
| 19.1 ± 9.1 |
| 1.4 ± 0.4 |
CL, plasma clearance; F, oral bioavailability.
↵ a tmax is presented as median (observed range).