Exposures of buspirone, 6-OH-buspirone, and 1-PP in male Sprague-Dawley rats after single intra-arterial or oral administration of buspirone
Buspirone | 6-OH-buspirone | 1-PP | |
|---|---|---|---|
| Buspirone, 5 mg/kg i.a. (n = 3) | |||
| Cmax (μM) | 5.51 ± 0.65 | 0.26 ± 0.14 | 0.69 ± 0.05 |
| AUC (μM * h) | 3.18 ± 0.38 | 0.39 ± 0.18 | 2.24 ± 0.31 |
| Buspirone, 10 mg/kg p.o. (n = 3) | |||
| Cmax (μM) | 0.04 ± 0.02 | 0.26 ± 0.06 | 0.69 ± 0.19 |
| AUC (μM * h) | 0.09 ± 0.03 | 1.09 ± 0.21 | 4.41 ± 0.56 |