Steady-state concentrations of buspirone and 6-OH-buspirone, and 5-HT1A receptor occupancy in the hippocampus and dorsal raphe after intravenous infusions of buspirone
Rat ID | Infusion Rate | Buspirone iCss | 6-OH-buspirone Css | 5-HT1A Receptor Occupancy | ||
|---|---|---|---|---|---|---|
| Hippocampus | Dorsal Raphe | |||||
| mg/kg/h | μM | μM | % | |||
| A | 12.0 | 11.1 ± 0.1 | 1.7 ± 0.3 | 95 | 100 | |
| B | 12.0 | 12.0 ± 0.5 | 1.6 ± 0.1 | 85 | 100 | |
| C | 4.0 | 6.36 ± 1.92 | 0.29 ± 0.04 | 72 | 96 | |
| D | 1.3 | 1.27 ± 0.09 | 0.11 ± 0.01 | 44 | 87 | |
| E | 0.45 | 0.46 ± 0.12 | 0.04 ± 0.02 | 28 | 53 | |