Steady-state concentrations and 5-HT1A receptor occupancy in the hippocampus and dorsal raphe after intravenous infusions of 6-OH-buspirone
Rat I.D. | Infusion Rate | Css | 5-HT1A Receptor Occupancy | ||
|---|---|---|---|---|---|
| Dorsal Raphe | Hippocampus | ||||
| mg/kg/h | μM | % | |||
| 1 | 23.7 | 22.4 ± 2.8 | 90 | 85 | |
| 2 | 23.7 | 24.1 ± 1.4 | 96 | 98 | |
| 3 | 23.7 | 20.0 ± 2.4 | 93 | 93 | |
| 4 | 11.9 | 12.1 ± 0.6 | 77 | 75 | |
| 5 | 11.9 | 11.0 ± 2.2 | 86 | 77 | |
| 6 | 11.9 | 11.2 ± 0.5 | 85 | 78 | |
| 7 | 2.4 | 2.3 ± 0.2 | 55 | 35 | |
| 8 | 2.4 | 2.9 ± 0.3 | 78 | 52 | |
| 9 | 2.4 | 2.7 ± 0.1 | 74 | 44 | |