Metabolite balance in urine and feces
Values are shown as the percentage of dose (mean ± S.D., n = 4).
Metabolite | Functional Group/Metabolic Change | Urine | Feces | Total |
|---|---|---|---|---|
| Front peak | Not identifieda | <0.1 | 0.1 | 0.1 ± 0.1 |
| M1 | Phenol, O-demethylated | 0.1 | 0.1 ± 0.1 | |
| M2 | Carboxylic acid (oxidized side chain) | <0.1 | 0.5 | 0.6 ± 0.5 |
| M3 | Alcohol, O-demethylated | <0.1 | 0.6 | 0.6 ± 0.4 |
| M4 | Phenol, O-dealkylated | <0.1 | <0.1 | |
| M6 | O-Glucuronide of M4 | <0.1 | <0.1 | |
| Aliskiren | (Parent compound) | 0.4 | 77.5 | 79.8 ± 3.0 |
| P62 | M12: N-acetyl derivative | 1.0 | 1.0 ± 0.1 | |
| M13, M14: partly characterized (+C3H4O2) | ||||
| Traces | Unidentified | <0.1 | 1.5 | 1.6 ± 0.7 |
| Not analyzed | 9.7 | 9.7 ± 3.1 | ||
| Total 14C |
| 0.6 | 90.9 | 91.5 ± 4.5 |
↵ a Not unambiguously identified; possible 3-amino-2,2-dimethylpropionamide, or a hydrolysis or oxidation product thereof.