IPRL and metabolism data for α1-adrenoceptor antagonists in series 1
Compound | IPRL Data | Rat Liver Microsomes Half-life | ||
|---|---|---|---|---|
| Hepatic Extraction Ratio | Percentage of Dose in Bile | |||
| min | ||||
| UK-191,005 | 0.7 | 90 | >120 | |
| (2) | 0.7 | 100 | >120 | |
| (3) | 0.75 | 90 | >120 | |
| (4) | 0.8 | 90 | >120 | |