TABLE 2
IPRL and metabolism data for α1-adrenoceptor antagonists in series 1
Compound
IPRL Data
Rat Liver Microsomes Half-life
Hepatic Extraction Ratio
Percentage of Dose in Bile
min
UK-191,005
0.7
90
>120
(2)
0.7
100
>120
(3)
0.75
90
>120
(4)
0.8
90
>120