Mean pharmacokinetic parameters of UK-191,005 in the rat and dog
Parameter | UK-191005 | ||
|---|---|---|---|
| Rat | Dog | ||
| n | 5 | 2 | |
| Intravenous dose (mg/kg) | 3 | 0.5 | |
| Elimination half-life (h) | 1.4 ± 0.3 | 2.4 | |
| Plasma clearance (ml/min/kg) | 135 ± 2 | 47 | |
| Unbound plasma clearance (ml/min/kg) | 2700 | 470 | |
| Volume of distribution (l/kg) | 9.3 ± 3.9 | 10 | |
| Unbound volume of distribution (l/kg) | 186 | 100 | |