Matrix and Collection Timea | M4 | M5 | Tigecycline |
---|---|---|---|
Serum | |||
−2 h | N.D.b | 10.5 ± 3.9c | 155 ± 39.0 |
24 h | N.D. | 7.4 ± 2.6 | 120 ± 18.2 |
48 h | N.D. | 3.9 ± 1.3 | 77.1 ± 21.4 |
Urine | |||
0-4 h | 12.7 ± 10.0d | 124 ± 112 | 4420 ± 715 |
4-8 h | 19.6 ± 9.58 | 181 ± 93.7 | 2720 ± 1215 |
8-24 h | 67.7 ± 29.9 | 555 ± 255 | 4910 ± 1540 |
24-48 h | 59.3 ± 33.7 | 476 ± 297 | 2920 ± 1150 |
Total Urine (0-48 h) | 159 ± 77.6 | 1340 ± 695 | 15000 ± 2980 |
↵ a Time is expressed relative to the final tigecycline dose.
↵ b N.D. indicates that the metabolite was below the limit of detection (2.1 ng/ml).
↵ c Values for serum are mean ± S.D. of concentration in serum (ng/ml).
↵ d Values for urine are mean ± S.D. of amount of compound excreted in each urine collection (μg).