Comparison of P-gp protein level and kinetic parameters with those in Caco/WT cells
Proteina | Quinidine AB | Quinidine BA | Digoxin BA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Km | Vmax | Km | Vmax | Km | Vmax | |||||
| Caco/WT | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |||
| Caco/hPXR | 4.5 | 4.0 | 4.3 | 2.5 | 2.1 | 1.5 | 1.7 | |||
| MDCK-MDR1 | 8.9 | 8.8 | 9.6 | 8.7 | 17.1 | 7.9 | 4.8 | |||
↵ a Data from Korjamo et al., 2006.