Correlation coefficients between thyroxine glucuronidation and other glucuronidations in microsomes from 12 human livers
Activity (Isoform) | Substrate Concentration | r | p |
|---|---|---|---|
| μM | |||
| Bilirubin O-glucuronidation | 10 | 0.855 | <0.001 |
| (UGT1A1) | |||
| Estradiol 3-O-glucuronidation | 100 | 0.827 | <0.0001 |
| (UGT1A1) | |||
| Chenodeoxycholic acid 24-O-glucuronidation | 10 | −0.080 | N.S. |
| (UGT1A3) | |||
| Imipramine N-glucuronidation | 500 | 0.135 | N.S. |
| (UGT1A3 and UGT1A4) | |||
| Serotonin O-glucuronidation | 1000 | 0.522 | <0.05 |
| (UGT1A6) | |||
| Propofol O-glucuronidation | 30 | 0.330 | N.S. |
| (UGT1A9) | |||
| Morphine 3-O-glucuronidation | 250 | −0.035 | N.S. |
| (UGT2B7) |
|
|
|
N.S., not significant.