Subject | Raltegravir | Radioactivity | Raltegravir/Radioactivity | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AUC0-t ha | Cmax | Tmax | AUC0-t h | Cmax | Tmax | AUC | Cmax | ||||||
μM · h | μM | h | μM Eq · h | μM Eq | h | ||||||||
1 | 9.45 | 3.39 | 1.0 | 11.41 | 3.96 | 1.0 | 0.83 | 0.86 | |||||
2 | 4.04 | 1.92 | 1.0 | 7.33 | 2.80 | 1.0 | 0.55 | 0.69 | |||||
3 | 15.69 | 4.86 | 1.0 | 19.33 | 5.70 | 1.0 | 0.81 | 0.85 | |||||
4 | 7.95 | 4.11 | 1.0 | 12.10 | 5.58 | 1.0 | 0.66 | 0.74 | |||||
5 | 9.05 | 5.51 | 0.5 | 13.01 | 6.60 | 0.5 | 0.70 | 0.83 | |||||
6 | 16.76 | 5.53 | 1.0 | 23.34 | 6.99 | 1.0 | 0.72 | 0.79 | |||||
7 | 14.21 | 7.46 | 0.5 | 19.14 | 8.26 | 0.5 | 0.74 | 0.90 | |||||
8 | 13.09 | 6.77 | 1.0 | 22.45 | 9.54 | 1.0 | 0.58 | 0.71 | |||||
Mean | 11.28 | 4.94 | 0.9 | 16.01 | 6.18 | 0.9 | 0.70 | 0.80 | |||||
S.D. | 4.36 | 1.80 | 0.2 | 5.82 | 2.18 | 0.2 | 0.10 | 0.08 |
↵ a t represents the last time point at which concentrations were above the limit of quantitation (20-24 h for raltegravir, 12-20 h for radioactivity).