Km | Vmax | Vmax/Kma | Vmax/Kmb | |
---|---|---|---|---|
μM | pmol/min/pmol P450 | |||
Deltamethrin rat P450s | ||||
CYP2C6 | 21.6 ± 9.4 | 150.0 ± 36.6 | 6.9 | 3.4 ± 0.3 |
CYP2C11 | 31.9 ± 25.7 | 205.8 ± 107.6 | 6.5 | 5.2 ± 0.7 |
CYP3A2 | 6.4 ± 3.8 | 25.9 ± 5.8 | 4.0 | 2.1 ± 0.2 |
Deltamethrin human P450s | ||||
CYP2C8 | 10.2 ± 9.5 | 42.7 ± 16.6 | 4.2 | 1.6 ± 0.1 |
CYP2C19 | 9.0 ± 5.6 | 61.6 ± 17.7 | 6.8 | 2.2 ± 0.5 |
CYP3A5 | 4.8 ± 0.6 | |||
Esfenvalerate rat P450s | ||||
CYP2C6 | 38.2 ± 26.2 | 158.2 ± 72.8 | 4.1 | 3.2 ± 0.3 |
CYP2C11 | 33.5 ± 21.8 | 219.4 ± 92.8 | 6.5 | 4.4 ± 0.4 |
CYP3A2 | 4.3 ± 1.8 | 39.5 ± 6.1 | 9.2 | 2.4 ± 0.5 |
Esfenvalerate human P450s | ||||
CYP2C8 | 19.1 ± 11.6 | 59.2 ± 21.6 | 3.1 | 1.6 ± 0.3 |
CYP2C9*1 | 24.3 ± 5.6 | 79.8 ± 6.3 | 3.3 | 2.9 ± 0.2 |
CYP2C19 | 4.1 ± 2.2 | 64.4 ± 12.3 | 15.7 | 4.4 ± 0.6 |
CYP3A5 |
|
|
| 4.7 ± 0.7 |