Comparisons of rHuEPO pharmacokinetics obtained via noncompartmental analysis in various species after i.v. doses
Species | Body Weight | Doses | CL | Vss |
|---|---|---|---|---|
| kg | IU/kg | ml/h/kg | ml/kg | |
| Rat | 0.346 (0.31-0.36) | 450-4050 (3a) | 12.97-16.03 | 115-118 |
| 0.211 (0.2-0.222) | 1, 5, 25 μg/kgb (3) | 19.6-29.4 | 108-123 | |
| Rabbit | 2.37 (2.38-2.67) | 1000-10,000 (3) | 9.9-13.98 | 52.4-59.1 |
| Monkey | 3.2c | 500-4000 (3) | 6.65-18.11 | 59.8-121 |
| Dog | 11 (9-14) | 200,000 cpm/kgd (1) | 11 | 142 |
| Sheep | 29.4 | 0.052-0.16d 1) | 37.73 | 105 |
| 50 (40-60) | 10-1000 (3) | 4.46-12.3 | 48.3-72 | |
| Human | 70 (56-89) | 10-100 (5) | 3.70-14.68 | 39.5-89.0 |
↵ a The number of dosages evaluated in the original study.
↵ b Equivalent to 180, 900, and 4500 IU/kg.
↵ c Mean body weight for male cynomolgus monkeys (Allison, 1960).
↵ d 125I-rHuEPO was used.