TABLE 2

Comparisons of pharmacologic parameters of rHuEPO

Species	S_max	SC₅₀	IC₅₀
		mIU/ml
Rat^a	1.87	65.37	1.79 g/dl^b
Monkey^c	1.92	153
Human^d	4.25	26.53	38.71 × 10¹⁰ cells/l^d
Human^e	1.53	45	2.88 g/dl^b

↵ a Taken from the original study.
↵ b Represented as unit of hemoglobin.
↵ c Remodeled PD data from Ramakrishnan et al. (2003).
↵ d Represented as reticulocyte units.
↵ e Remodeled PD data from multiple dosing studies (Ramakrishnan et al., 2004).