PZA Alone Group | PZA + Long-Term Silibinin Exposure Group | PZA + Concomitant Short-Term Silibinin Exposure Group | |
---|---|---|---|
Blood | |||
AUC (min/μg/ml) | 19,300 ± 3800 | 18,200 ± 4500 | 20,200 ± 2100 |
CL (ml/kg/min) | 2.52 ± 0.8 | 2.30 ± 0.29 | 2.12 ± 0.49 |
t1/2 (min) | 204 ± 33 | 189 ± 14 | 227 ± 79 |
Cmax (μg/ml) | 119 ± 31 | 145 ± 46 | 144 ± 22 |
Brain | |||
AUC (min/μg/ml) | 7900 ± 1700 | 6900 ± 710 | 7800 ± 880 |
t1/2 (min) | 204 ± 47 | 165 ± 18 | 206 ± 38 |
Cmax (μg/ml) | 23.7 ± 3.7 | 27.7 ± 1.5 | 28.6 ± 2.6 |
Bile | |||
AUC (min/μg/ml) | 20,500 ± 4200 | 14,900 ± 2300 | 23,900 ± 3600 |
t1/2 (min) | 193 ± 29 | 123 ± 25 | 257 ± 45 |
Cmax (μg/ml) | 91.7 ± 13.8 | 85.5 ± 10.7 | 95 ± 9.1 |
AUCbrain/AUCblood | 0.42 ± 0.05 | 0.44 ± 0.12 | 0.40 ± 0.08 |
AUCbile/AUCblood | 1.02 ± 0.16 | 0.67 ± 0.10 | 0.96 ± 0.16 |
CL, clearance.