Species | Cmax | AUC0-12 h | t1/2 | ||||||
---|---|---|---|---|---|---|---|---|---|
First Dosing | Second Dosing | First Dosing | Second Dosing | First Dosing | Second Dosing | ||||
μg/ml | μg · h/ml | h | |||||||
Rat | 18.5 ± 1.5 | 4.9 ± 0.9* | 106.4 ± 19.2 | 27.5 ± 7.1* | 1.4 ± 0.2 | 2.2 ± 0.9 | |||
Mouse | 29.9 | 31.1 | 154.6 | 183.1 | 4.0 | 2.9 | |||
Dog | 23.5 ± 4.3 | 15.9 ± 4.0* | 98.6 ± 22.9 | 69.1 ± 19.2* | 1.6 ± 0.1 | 1.9 ± 0.6 |
↵* Significantly different from first dosing (P < 0.05).