TABLE 3

Pharmacokinetic parameters of intravenously administered TSU-68 (50 mg/kg) to rats with and without oral administration of TSU-68 (200 mg/kg) 12 h beforehand

Each value shown is mean with S.D. (n = 5).

Prior Oral Dosing	AUC_0-∞	CL_p	t_1/2	Vd_ss
	μg · h/ml	ml/h/kg	h	l/kg
(−)	318.5 ± 47.8	160.2 ± 27.0	1.06 ± 0.07	0.24 ± 0.04
(+)	205.6 ± 24.3^*	245.9 ± 28.6^*	0.56 ± 0.11^*	0.20 ± 0.03

↵* Significantly different from value without prior dosing (P < 0.05).