TABLE 3

Chemical shifts of protons and carbons in 1H NMR and 13C NMR spectra of major (M-11b) and minor (M-11a) constituents of reference products obtained from imidafenacinEmbedded Image

Position of Proton
1H NMR Data (in D2O)
Major Constituent (M-11b)
Minor Constituent (M-11a)
1 2.18a (3Hb, sc) 2.11a (3Hb, sc)
2 2.82 (2H, m) 2.79 (2H, m)
3 3.45 (2H, m) 3.41 (2H, m)
5 5.26 (1H, s) 5.43-5.47d (1H, d, J = 8.1e)
6 5.33 (1H, s) 5.43-5.47d (1H, d, J = 8.1e)
8, 9, and 10 7.39-7.49 (10H, m) 7.40-7.48 (10H, m)
13
8.45 (1.3H, s)
8.45 (2H, s)
Position of Carbon
13C-NMR Data (in D2O)xc
Major Constituent (M-11b)
Minor Constituent (M-11a)
1 14.61a 14.48a
2 39.04 38.49
3 43.49 42.90
4 61.95-61.99f 61.95-61.99f
5 87.61 80.22 or 85.78f
6 93.10 80.22 or 85.78f
7 144.2-144.4f 144.2-144.4f
8, 9, and 10 130.7-131.8f 130.7-131.8f
11 170.8 169.5
12 181.9-182.2f 181.9-182.2f
13
173.8
173.8

  • ↵ a Chemical shifts are reported in parts per million.

  • ↵ b Intensities are represented as number of protons.

  • ↵ c Multiplicity: s, singlet; d, doublet; m, multiplet.

  • ↵ d These proton signals could not be distinguished.

  • ↵ e Coupling constants (J) are given in Hertz.

  • ↵ f These carbon signals could not be distinguished.