TABLE 3

Kinetic parameters PSnet, b to a and PSapical of rosuvastatin in OATP1B1/MRP2- and OATP1B1/MDR1 double-transfected MDCKII cells

Data shown in Fig. 4 were used to determine the Km, Vmax, and Pdif values. These parameters were determined by fitting the data using the nonlinear least-squares method. Each point represents the mean ± computer-calculated S.D. (n = 3).




Km

Vmax

Pdif
μM pmol/min/mg μl/min/mg
OATP1B1/MRP2
    PSnet 29.9 ± 4.5 274 ± 40 0.258 ± 0.148
    PSapical 34.3 ± 6.7 329 ± 64 0.335 ± 0.243
OATP1B1/MDR1
    PSnet 21.7 ± 2.1 106 ± 9 0.0868 ± 0.0390
    PSapical
40.1 ± 6.3
152 ± 24
0.101 ± 0.081