Pharmacokinetic parameters of rosuvastatin during constant i.v. infusion into SD rats and EHBRs
Each point represents the mean ± S.E. (n = 3).
Cp, ss | CLtot, p | CH, ss | Kp, H | Vbile, ss | CLbile, p | CLbile, H | ||
|---|---|---|---|---|---|---|---|---|
| nM | ml/min/kg | nM | pmol/min/kg | ml/min/kg | ||||
| SD rat | 13.3 ± 0.9 | 50.6 ± 3.2 | 139 ± 6 | 10.6 ± 1.1 | 493 ± 24 | 37.6 ± 3.8 | 3.55 ± 0.18 | |
| EHBR | 35.1 ± 1.8** | 19.1 ± 1.0** | 190 ± 13 | 5.41 ± 0.11* | 359 ± 24 | 10.2 ± 0.4* | 1.89 ± 0.10** | |
Cp, ss, plasma steady-state concentration (mean plasma concentration at 300 min); CLtot, p, total plasma clearance calculated by dividing the infusion rate by Cp, ss; CH, ss, hepatic steady-state concentration (mean hepatic concentration at 300 min); Kp, H, liver/plasma concentration ratio at steady state, which was calculated by dividing the CH, ss value by the Cp, ss value; Vbile, ss, steady-state biliary excretion rate (mean biliary excretion rate during 240-300 min); CLbile, p, biliary excretion clearance relative to the plasma concentration, which was calculated by dividing the Vbile, ss value by the Cp, ss value; CLbile, H, biliary excretion clearance relative to the hepatic concentration, which was calculated by dividing the Vbile, ss value by the CH, ss value.
↵* P < 0.05.
↵** P < 0.01.