Solubilizing Agent | Tested Concentration Range | Solubility of Rifalazil | Estimated Relative Volumetric Productivity for 32-Hydroxy-rifalazila | ||
---|---|---|---|---|---|
mg/l | |||||
None | 10 | 1.0 | |||
Tween 80 | 0.01-1% w/v | >1000b | 0.6c | ||
Alkamuls EL-620 | 0.01-1% w/v | >1000b | 0.6c | ||
Polyvinylpyrrolidone, molecular mass 10 kDa | 0.2-5% w/v | >100b | 0.8c | ||
Polyvinylpyrrolidone, molecular mass 40 kDa | 0.2-5% w/v | >100b | 1.1c | ||
Bovine serum albumin | 1-20 mg/ml | >100b | 0.6c | ||
Glycerol | 1-20% v/v | 10-50 | 0.3d |
↵ a Estimated from the HPLC peak area.
↵ b Estimated at the lowest tested concentration of the solubilizing agent.
↵ c Estimated at the lowest tested concentration of the solubilizing agent; increasing concentrations of the agent resulted in a significant decrease of the estimated yield.
↵ d At 20% glycerol.