TABLE 2

Concentrations of bPiDDB in brain and plasma from bPiDDB-treated rats

Concentrations of bPiDDB in brain and plasma and brain/plasma ratios and percent recoveries of plasma and brain ¹⁴C in rat plasma and brain at time points of 1, 5, 10, 15, 20, and 60 min after administration of 5.6 mg/kg s.c.

Time	Plasma Conc., n = 4	Brain Conc., n = 4	Brain/Plasma Ratio	% Recovery of Plasma ¹⁴C^a	% Recovery of Brain ¹⁴C^a
	μg/ml	μg/g
1 min	0.16 ± 0.03	0.01 ± 0.01*	0.06 ± 0.05	101 ± 0.5	99.8 ± 0.23
5 min	0.51 ± 0.01	0.09 ± 0.01	0.18 ± 0.01	98.4 ± 0.09	98.6 ± 0.03
10 min	0.89 ± 0.10	0.33 ± 0.06	0.37 ± 0.04	99.3 ± 0.11	99.7 ± 0.04
15 min	0.56 ± 0.09	0.21 ± 0.04	0.38 ± 0.11	98.7 ± 0.12	101 ± 0.03
20 min	0.41 ± 0.05	0.18 ± 0.03	0.46 ± 0.09	99.1 ± 0.06	102 ± 0.02
60 min	0.18 ± 0.02	0.10 ± 0.01	0.51 ± 0.15	98.2 ± 0.10	98.1 ± 0.02

↵* Not significant compared with control.
↵ a Indicates recovery of ¹⁴C radiolabel in the HPLC effluent.