Metabolic parameters for N-dealkylated VP, O-demethylated VP, and NVP in rat small intestinal microsomes
Each value represents the mean ± S.D. (n = 4).
N-Dealkylated VP | O-Demethylated VP | NVP | |||||||
|---|---|---|---|---|---|---|---|---|---|
| S | R | S | R | S | R | ||||
| Km (μM) | 125.3 ± 18.2 | 65 ± 11.2* | 140 ± 52.2 | 74.4 ± 11.3 | 79.6 ± 18.6 | 59.5 ± 11.6 | |||
| Vmax (pmol/min/mg protein) | 11.2 ± 1.9 | 13.8 ± 5.2 | 6.7 ± 2.2 | 8.7 ± 2.7 | 13.1 ± 3.4 | 16.0 ± 3.4 | |||
| Vmax/Km (μl/min/g protein) | 0.09 ± 0.02 | 0.21 ± 0.08* | 0.06 ± 0.03 | 0.12 ± 0.06 | 0.07 ± 0.03 | 0.27 ± 0.06* | |||
↵* p < 0.05 (versus S-enantiomer).