Plasma protein binding of zoledronic acid and ibandronate
Unbound fractions (mean ± S.D., expressed in %) of 14C-zoledronic acid and 14C-ibandronate in pooled plasma from rat and dog and three individual human plasma samples. Concentrations are based on measurement of total 14C-radioactivity.
Nominal Concentration (ng/ml) | |||||||
|---|---|---|---|---|---|---|---|
| 2 | 20 | 200 | 2000 | ||||
| Zoledronic acid | |||||||
| Rat plasma | 19.6 ± 1.4 | 13.1 ± 0.6 | 12.1 ± 0.8 | 16.4 ± 0.6 | |||
| Dog plasma | 50.9 ± 2.1 | 54.7 ± 1.1 | 62.5 ± 1.7 | 64.0 ± 0.7 | |||
| Human plasma | 59.6 ± 2.4 | 65.4 ± 2.0 | 71.7 ± 0.2 | 76.9 ± 1.9 | |||
| Ibandronate | |||||||
| Rat plasma | 28.9 ± 1.4 | 24.2 ± 2.6 | 32.4 ± 1.3 | 48.5 ± 1.7 | |||
| Dog plasma | 59.3 ± 3.8 | 64.7 ± 1.3 | 71.6 ± 0.6 | 75.1 ± 1.5 | |||
| Human plasma | 68.9 ± 13.3 | 73.8 ± 1.0 | 76.3 ± 1.1 | 78.6 ± 1.0 | |||