Name | Mr | cLogP | cLogD | Acidic pKa | Basic pKa | Measured fumic | Calculated fumic | Δa | NNb | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Mean | S.E. | ||||||||||
Albendazole | 265 | 3.46 | 3.06 | 11.2 | 5.62 | 0.69 | 0.02 | 0.65 | 0.04 | 1 | |
Amitriptyline | 277 | 4.85 | 3.15 | 9.18 | 0.27 | 0.02 | 0.14 | 0.13 | 0 | ||
Carbamazepine | 236 | 2.38 | 2.67 | 0.97 | 0.04 | 0.82 | 0.15 | 0 | |||
Chlorimipramine | 315 | 5.92 | 3.54 | 9.46 | 0.09 | 0.01 | 0.08 | 0.01 | 0 | ||
Chlorpromazine | 319 | 5.3 | 2.87 | 9.41 | 0.15 | 0.01 | 0.03 | 0.12 | 0 | ||
Clozapine | 327 | 3.71 | 3.35 | 7.14 | 0.45 | 0.03 | 0.3 | 0.15 | 0 | ||
Colchicine | 399 | 1.2 | 0.92 | 1.01 | 0.04 | 0.93 | 0.07 | 0 | |||
Desipramine | 266 | 4.47 | 1.43 | 10.4 | 0.35 | 0.01 | 0.26 | 0.09 | 0 | ||
Diazepam | 285 | 2.96 | 2.96 | 3.4 | 0.77 | 0.03 | 0.55 | 0.22 | 0 | ||
Erythromycin | 734 | 1.61 | 2.08 | 8.16 | 0.84 | 0.02 | 0.85 | 0.01 | 0 | ||
Imipramine | 280 | 5.04 | 2.79 | 9.49 | 0.35 | 0.02 | 0.57 | 0.22 | 0 | ||
Indomethacin | 358 | 4.18 | -0.16 | 3.96 | 0.91 | 0.03 | 0.72 | 0.19 | 0 | ||
Ketoconazole | 531 | 3.38 | 2.71 | 6.33 | 0.27 | 0.08 | 0.27 | 0 | 0 | ||
Ketoprofen | 254 | 2.76 | -0.25 | 4.23 | 0.92 | 0.06 | 0.93 | 0.01 | 0 | ||
Midazolam | 326 | 3.42 | 3.92 | 5.59 | 0.65 | 0.01 | 0.64 | 0.01 | 2 | ||
Pimozide | 462 | 6.4 | 4.77 | 12 | 9.42 | 0.01 | 0.00 | 0.01 | 0 | 0 | |
Piroxicam | 331 | 1.89 | -1.15 | 4.5 | 3.8 | 1.02 | 0.02 | 0.98 | 0.02 | 1 | |
Prednisone | 358 | 1.66 | 1.57 | 12.4 | 0.98 | 0.06 | 0.84 | 0.14 | 1 | ||
Promethazine | 284 | 4.4 | 2.29 | 8.98 | 0.29 | 0.01 | 0.2 | 0.09 | 0 | ||
Propranolol | 259 | 2.75 | 1.27 | 9.14 | 0.62 | 0.02 | 0.46 | 0.16 | 1 | ||
Quinidine | 324 | 2.79 | 1.6 | 12.8 | 9.28 | 0.72 | 0.06 | 0.65 | 0.07 | 0 | |
Sulindac | 356 | 3.16 | 0.55 | 4.26 | 1.08 | 0.01 | 0.89 | 0.11 | 0 | ||
Tenidap | 321 | 2.3 | -0.16 | 4.5 | 0.63 | 0.03 | 0.95 | 0.32 | 0 | ||
Tolbutamide | 270 | 2.5 | 0.39 | 5.12 | 0.96 | 0.06 | 0.98 | 0.02 | 0 | ||
Trimeprazine | 298 | 4.8 | 2.53 | 9.34 | 0.23 | 0.01 | 0.12 | 0.11 | 0 | ||
Verapamil | 455 | 4.47 | 2.33 | 8.97 | 0.59 | 0.03 | 0.43 | 0.16 | 1 | ||
Warfarin | 308 | 2.9 | 0.61 | 4.5 |
| 0.80 | 0.08 | 0.85 | 0.05 | 0 |