TABLE 3

Effects of bromocriptine on the steady-state kinetics of 7BQ debenzylation by human liver microsomes


HLM Sample

S0.5 for 7BQ

nH for 7BQ
Control
Bromocriptine
Control
Bromocriptine
μM
HLM2 139 ± 7 270 ± 32 2.9 ± 0.2 5 ± 0.5
HLM3 145 ± 20 256 ± 76 2.2 ± 0.3 2.8 ± 0.2
HLM4 119 ± 0.5 241 ± 29 3.3 ± 0.14 3.8 ± 0.3
HLM5
114 ± 5
222 ± 6
3.3 ± 0.6
4.7 ± 0.2