Mean pharmacokinetic parameters for total radioactivity in rats, monkeys, and mice after oral administration of [14C]torcetrapib-A
Animal | Tmax | Cmax | AUC(0-tlast) | AUC(0-∞) | Estimate of t1/2 | |
|---|---|---|---|---|---|---|
| h | ng Eq/ml | ng Eq/h/ml | h | |||
| Male rats (n = 3) | 6.7 | 3020 | 48,300 | 49,400 | 8.6 | |
| Female rats (n = 3) | 5.3 | 4150 | 76,900 | 80,700 | 10.5 | |
| Mean | 6.0 | 3590 | 62,600 | 65,100 | 9.6 | |
| Male monkey (n = 3) | 20 | 7230 | 297,000 | 341,000 | 83.0 | |
| Female monkey (n = 2) | 14 | 4620 | 189,000 | 227,000 | 76.0 | |
| Mean | 17.6 | 6190 | 254,000 | 295,000 | 80.0 | |
| Female mice | 8.0 | 9810 | 107,000 | 110,000 | 12.2 | |
| Male mice | 2.0 | 9380 | 77,700 | 79,200 | 11.7 | |
| Mean | 5.0 | 9600 | 92,400 | 94,600 | 12.0 | |