Assigned Km | A → B | B → A | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Jmax
*
| β | Jmax
*
| β | |||||||||||
nmol/min | μM | μM | nmol/min | μM | μM | |||||||||
Case 1 (CLd = 0.01 ml/min) | ||||||||||||||
0.05 μM | 0.134 | 0.252 | 12.0 | 2.10 | 0.288 | 0.226 | 11.2 | 2.12 | ||||||
0.5 μM | 0.134 | 2.49 | 17.4 | 1.62 | 0.288 | 2.23 | 16.2 | 1.63 | ||||||
5 μM | 0.135 | 23.9 | 39.0 | 1.20 | 0.290 | 21.5 | 36.0 | 1.21 | ||||||
25 μM | 0.138 | 109 | 116 | 1.04 | 0.296 | 99.3 | 107 | 1.05 | ||||||
50 μM | 0.139 | 205 | 209 | 1.02 | 0.298 | 188 | 192 | 1.02 | ||||||
Case 2 (CLd = 0.1 ml/min) | ||||||||||||||
0.05 μM | 0.0640 | 0.173 | 1.49 | 1.49 | 0.0825 | 0.0874 | 0.857 | 1.46 | ||||||
0.5 μM | 0.0640 | 1.60 | 3.57 | 1.21 | 0.0825 | 0.967 | 2.19 | 1.20 | ||||||
5 μM | 0.0640 | 15.8 | 17.7 | 1.04 | 0.0825 | 9.78 | 11.2 | 1.05 | ||||||
25 μM | 0.0640 | 78.6 | 79.4 | 1.01 | 0.0826 | 48.8 | 49.6 | 1.01 | ||||||
50 μM | 0.0640 | 156 | 156 | 1.00 | 0.0826 | 97.4 | 97.9 | 1.00 | ||||||
Case 3 (CLd = 1 ml/min) | ||||||||||||||
0.05 μM | 0.00671 | 0.160 | 0.233 | 1.06 | 0.00848 | 0.0908 | 0.123 | 1.04 | ||||||
0.5 μM | 0.00671 | 1.58 | 1.78 | 1.03 | 0.00848 | 0.930 | 1.03 | 1.02 | ||||||
5 μM | 0.00671 | 15.8 | 16.0 | 1.01 | 0.00848 | 9.22 | 9.40 | 1.01 | ||||||
25 μM | 0.00672 | 79.4 | 79.3 | 1.00 | 0.00849 | 46.4 | 46.5 | 1.00 | ||||||
50 μM | 0.00671 | 158 | 158 | 1.00 | 0.00849 | 92.8 | 92.8 | 1.00 |
↵* True Vmax = 0.5 nmol/min